Read the network.
Change its dynamics.

We combine large-scale electrophysiology, targeted interventions and engineering to investigate healthy and pathological brain activity.

Neural dynamics

How networks organize information

Our research explores the coordinated activity of neurons and circuits, including oscillations, hippocampal network dynamics, memory and sensory processing. Recording across multiple sites lets us ask how local activity relates to the behaviour of the larger network.

We combine high-density extracellular recording with quantitative analysis to link neural activity across scales.

Published experimental methods and electrophysiological traces from Takeuchi et al., Brain (2021).

Closed-loop neuromodulation

Timing is part of the intervention

Closed-loop approaches use ongoing neural activity to guide stimulation. We investigate interventions that interact with pathological rhythms, with particular interest in epilepsy and the modulation of circuits relevant to neuropsychiatric conditions.

Our published work includes seizure-rhythm driven medial septal stimulation in rats, phase-targeted stimulation during fear extinction in male rats, and the reinstatement of limbic gamma oscillations in rodent models.

Comparison of stimulation timing approaches. Takeuchi et al., Brain (2021).

Neurotechnology & translation

New tools open new questions

We develop approaches for recording neural activity and delivering spatially and temporally targeted stimulation. Our methods include EEG, high-density silicon-probe recordings, optogenetics, intersectional short-pulse stimulation (ISP) and neural data analysis.

The goal is to connect mechanistic questions in experimental models with the challenges of therapeutic translation. Experimental and clinical studies require distinct interpretation; preclinical findings do not establish clinical efficacy.